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History and Goals of Antiretroviral Therapy; Clinical Trials: Recent Assessments of Various Triple Nucleoside Regimens as HAART for Treatment-Naïve HIV-Infected Patients; Lower Efficacy With Stavudine, Didanosine, and ABC Triple NRTI Regimen; Tenofovir DF (TDF)/ABC/3TC Versus EFV/ABC/3TC in Antiretroviral-naïve HIV Patients; Atlantic Study: An Assessment of d4T/ddI/3TC; CLASS: Triple NRTI d4T/3TC/ZDV Versus NNRTI- and PI-based HAART; Efficacy From Trials With Quadruple PI-Sparing Therapy
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Breast Cancer and the Use of Statins; Warnings Issued for IBS Drugs; FDA Actions
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Animal Reservoirs for SARS; SARS Screening Identifies TB Cases Instead; Measles Outbreak Among Chinese Adoptees; Recovery of Vaccinia after Smallpox Inoculation; Risk of Hepatitis A in Travelers to Developing Countries
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The following summary of selected abstracts from 3 meetings will be published in multiple parts. The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) met in Chicago September 14-17, 2003. The Infectious Disease Society of America (IDSA) met in San Diego October 9-12, 2003. The American Society of Tropical Medicine and Hygiene met in Philadelphia December 3-7, 2003.
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Mupirocin application to the nose of hospitalized Staphylococcus aureus carriers did not decrease the incidence of nosocomial S aureus infection, but it did delay its appearance.
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Almost 1 in 20 Candida species isolated were misidentified by clinical laboratories; these errors have potential for engendering adverse clinical outcomes. C glabrata was the species most frequently misidentified.
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The primary therapeutic goals when initiating therapy in patients infected with HIV are maximal and long-lasting suppression of viral replication, maintenance or restoration of immunologic function, improvement of quality of life, and reduction of HIV-related morbidity and mortality.(1) Highly active antiretroviral therapy (HAART) using combinations of antiretroviral agents has been shown to achieve these goals to a significant degree and reduce morbidity and mortality in the population of HIV-infected patients.
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These data support the hypothesis that favorable survival that is associated with optimal debulking of advanced ovarian cancers is due to, at least in part, the underlying biologic characteristics of these cancers.
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In a retrospective review from the Royal Victoria Hospital in Montreal, among patients with heparin-induced thrombocytopenia, those who had underlying malignancy were found to have a greater risk for thrombotic events when compared to those without malignant disease.
